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Beyond its hypnotic effect, the DSIP DSIP exhibits documented pleiotropic properties: analgesic action via modulation of endogenous opioid pathways, anti-stress effects through the reduction of cortisol and ACTH, antioxidant and neuroprotective properties, and modulation of tolerance to ethanol and addictive substances

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Given the close association between the PI3K/Akt pathway, increased ROS and the progression of endometriosis (92,106), resveratrol may exert therapeutic effects by restoring redox balance and modulating ROS-driven signaling pathways

Frequency of the polymorphic T allele was found to be significantly positively associated with latitude, with an increase in degrees of latitude being associated with an increase in polymorphism frequency ( r 2 = 0.14, p =0.017)